Add-On Extended Dorsal Intercostal Artery Perforator Propellar Flap (AOE-DICAP) For The Reconstruction Of Large Posterior Trunk Defects

Introduction Reconstruction of large posterior trunk soft tissue defects poses a challenging problem. Until recently, these defects were reconstructed with multiple random pattern flaps, local pedicled muscle flaps and musculocutaneous flaps.The posterior intercostal arteries form the major angiosome of the trunk through multiple perforators to the skin.Some studies in the recent literature have highlighted the reliability of the classical DICAP flap in the posterior trunk reconstruction. Aim: To determine the efficacy, reliability and clinical outcomes of the add-on extended dorsal intercostal artery perforator propeller flaps (AOE-DICAP)for the reconstruction of large posterior trunk defects. Materials & Methods: Six patients (3 infants and 3 adults) with posterior trunk defects due to variousaetiologies were reconstructed with AOE-DICAP flap. Result: All flaps survived completely, except for superficial epidermolysis at the distal border of the flap in one patient that healed secondarily. Average follow up was 12 months. Conclusion: Add-on extended DICAP (AOE-DICAP) flap provides an excellent stable cover and a viable option for large median and para-median back defects reconstruction.

A sustained release of tablet granules associated with ZnS nanocrystals using Tamarind seed polysaccharide.

Tamarind seed polysaccharide (TSP) isolated from tamarind kernel powder was investigated for sustained release manners of salicylic acid drug. Tablet granules of salicylic acid were prepared, with two different grades of TSP and Cross linked TSP and embedded with chemically synthesized ZnS nanocrystals. Five different formulations made and the drug excipient mixtures were subjected to pre-formulation studies such as physicochemical studies, in vitro dissolution test, disintegration test, angle of repose and drug content. The physicochemical properties of tablets were found within the limits. Formulation F1 and F5 containing TSP and Cross linked were found to release the drug in sustained manner up to 24 hour and were stable under accelerated conditions of temperature for 6 months since there were no significant changes in drug content and physical parameters. This formulation was more comfortable to the user due to less erosion, faster and optimum pH of surrounding medium.